POTENCY OF CAFFEIC ACID COMPOUNDS IN OIL LEAVES (MORINGA OLEIFERA) AGAINST CARBONATE ANHYDRASE ENZYME AS ANTI-CANCER IN SILICO

Abstract

Moringa (Moringa oleifera) is a plant that can grow in tropical and subtropical areas. Cranberries are used as food and medicines to cure a variety of diseases. Cello contains a variety of active compounds, one of which is caffeic acid compound. The main mechanism of action of the caffeic acid compound is as an inhibitor of the enzyme carbonate anhydrase, which is being developed as an anti-cancer mechanism. The study aims to identify the potential of the caffeic acid compound in the Moringa oleifera leaf against the enzyme carbonate anhydrase as an anti-cancer in silico. Tests are carried out in silico (Molecular Docking) using a computing device with Pyrx software. Silico tests are conducted to predict pharmacokinetics and physiochemical properties, predict bioavailability, toxicity and continue with molecular docking. The inhibitory activity of carbonate anhydrase enzymes in silico is seen from the binding affinity values as well as the ligan-protein interaction.  It was concluded that caffeic acid has the same potent potential as acetozolamide as an inhibitor of carbonate anhydrase, which can be used as a candidate anti-cancer drug.