THE EFFECTS OF INCREASING PVP K-30 CONCENTRATIONS TO THE PHYSICAL QUALITY OF Mangifera indica L. And Syzygium polyanthum LEAF EXTRACT TABLET

Abstract

Diabetes mellitus (DM) is a chronic disease caused by decreased effectiveness of insulin resulting in abnormalities in carbohydrate, protein, and fat metabolism, potentially triggering increased triglyceride formation in the liver due to increased production and decreased VLDL catabolism. Treatment of diabetes and hypertriglyceridemia still using chemical drugs in the long term cannot be separated from unwanted side effects so a combination of Mangifera indica L. and Syzygium polyanthum leaf extracts is needed which can be used as antidiabetes and antihyperlipidemia which can reduce triglyceride levels in the body. This study aims to determine an impact of the binders concentration of PVP K-30 1,5%, 2%, and 2,5% to the physical qualities that fulfill the range of requirement. The extract was made by using maseration method with ethanol 96% as solvent. The tablet was produced  by using wet granulation method utilizing  PVP K-30 as the binding agent. The physical quality tests that cover the hardness, friability and disintegration time of the tablet. After that, the obtained data were statistically analyzed.The result of the study indicated that the increase of PVP K-30 concentrations 1,5, 2% dan 2,5%  in physical tests was able to  decrease the friability of the tablets, disintegration time and increase the hardness.  The statistical analysis result showed that there was significant difference in terms of the hardness and disintegration time of the tablets among the formulas. While, it was significantly difference in terms of friability in the formulas with the concentration of 2% (F2) and 2,5% (F3). Formula 2 with 2% concentrations is the optimum formula with physical qualities which is fulfill the requirements.