ANTIBACTERIAL ACTIVITY TEST OF ASHITABA LEAF WATER FRACTION OINTMENT FORMULATION (Angelica Keiskei (miq) Koidz) AGAINST STAPHYLOCOCCUS EPIDERMIDIS BACTERIA

Abstract

Acne is a condition in which the pores of the skin are blocked, causing inflamed pus pockets. One of the factors causing acne is bacteria. Staphylococcus epidermidis bacteria are bacteria found in acne. The use of medicinal plants is an alternative as a treatment for diseases including diseases caused by bacterial infections. Ashitaba leaves (Angelica Keiskei (miq) Koidz) positively contain saponin, tannin and flavonoid compounds which play a role as antibacterial. The purpose of this study was to determine the antibacterial activity of the formulation of the ointment preparation of the water fraction of ashitaba leaves against Staphylococcus epidermidis bacteria that cause acne, using the well diffusion test method. Observation of the inhibitory power was tested on ashitaba leaf extract and ointment preparations of ashitaba leaf water fraction with a concentration of water fraction Formula I 10%, Formula II 15%, Formula 20%. The results of this study are the formulation of ashitaba leaf extract ointment preparations can have inhibitory power against Staphylococcus epidermidis bacteria. The highest inhibition zone in Formula III with a water fraction concentration of 20% with an inhibition zone diameter value of 7.8 mm.