FORMULATIONS AND EVALUATIONS OF PHYSICAL QUALITY OF CROSCARMELLOSE SODIUM AS A DESINTEGRATOR OF KETOPROFEN TABLETS

Abstract

The use of disintegrating agents in a tablet formulation is used to speed up the disintegration time thereby influencing the release of the active ingredient (Ketoprofen) from the initial dosage form (tablet) which influences the start of the drug's action in the body. Croscarmellose sodium has characteristics that fulfill its properties as a disintegrating agent. The aim of this research is to determine the effective concentration of Croscarmellose sodium as a disintegrating agent using three test group formulations, namely 1^st Formulation which uses 1% Croscarmellose sodium, 2^nd Formulation  which uses 3% Croscarmellose sodium, 3^rdFormulation which uses 5% Croscarmellose sodium with a comparison 4^th formulation as a negative control without using Croscarmellose sodium and Ketoprofen tablets which have been widely circulated in the community as one of the analgesic, antipyretic and anti-inflammatory drug choices used as positive controls. The method used in this research is experimental. The results of the research show that variations in the concentration of disintegrating agents have a different influence on the physical quality of the tablets produced, based on the results of the Oneway Anova test analysis, it shows a significant value of 0.000 (p<0.05) and the Kruskal-Wallis shows a significant value of 0.10 (p >0.05). In testing the physical quality of tablets which was carried out based on the requirements set by the Indonesian Pharmacopoeia, the best results were obtained in Formula 1 which used Croscarmellose sodium 1%, with a tablet hardness value of 5.65 kg and a disintegration time value of 8.45 minutes which was close to the positive control results with values tablet hardness 10.23 kg and disintegration time value 7.57 minutes.